Contribution of vascular cell senescence to atherogenesis
نویسندگان
چکیده
منابع مشابه
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis
Inflammation is a central element of atherogenesis. Innate pathways contribute to vascular inflammation. However, the initial molecular process(es) starting atherogenesis remain elusive. The various risk factors, represented by particular compounds (activators), may cause altered cellular functions in the endothelium (e.g. vascular endothelial cell activation or -dysfunction), in invading cells...
متن کاملVascular smooth muscle cell senescence in atherosclerosis.
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their se...
متن کاملVascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.
BACKGROUND AND PURPOSE Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption, are emerging as potential risks for diverse neurological conditions. Because the accumulation of senescent cells in tissues is increasingly recognized as a critical step leading to age-related organ dysfunction, we evaluated whether senescent vascular cells are associated with c...
متن کاملDefective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However, the role of VSMC autophagy in cardiovascular disease is poorly understood. Therefore, we investigated the effect of defective autophagy on VSMC survival and phenotype and its significance in the development of postinjury neointima formation and atherosclerosis. Tissue-specific deletion of the e...
متن کاملSM22 Modulates Vascular Smooth Muscle Cell Phenotype During Atherogenesis
The function of cytoskeletal proteins in the modulation of vascular smooth muscle cell (SMC) phenotype during vascular disease is poorly understood. In this report, we used a combination of gene targeting and Cre/loxmediated cell fate mapping in mice to investigate the role of SM22 , an SMC-specific cytoskeletal protein of unknown function, in the development of atherosclerosis. In hypercholest...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
سال: 2008
ISSN: 0300-9173
DOI: 10.3143/geriatrics.45.295